KMID : 0545120170270071272
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Journal of Microbiology and Biotechnology 2017 Volume.27 No. 7 p.1272 ~ p.1275
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Antifungal Activities of Dimeric Sesquiterpenes, Shizukaols C and F, Isolated from Chloranthus japonicus Sieb.
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Kang Tae-Hoon
Lee Yun-Me Lee Won-Jung Hwang Eui-Il Park Ki-Duk Choi Gyung-Ja Moon Jae-Sun Park Ho-Yong Kim Sung-Uk
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Abstract
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Two dimeric sesquiterpenes were separated from Chloranthus japonicus Sieb. and identified as shizukaols C and F. They exhibited potent antifungal activities (MICs = 4-16 ¥ìg/ml) in vitro against various plant pathogenic fungi (Pythium ultimum, Phytophthora infestans, Botrytis cinerea, Colletotrichum lagenarium, Alternaria kikuchiana, and Magnaporthe grisea). Shizukaol C showed 88% and 91% protective activities in the greenhouse against Puccinia recondita (wheat leaf rust) and Phytophthora infestans (tomato late blight), respectively, at 100 ¥ìg/ml; shizukaol F exhibited 93% antifungal activity against Puccinia recondita at the same concentration. Therefore, these compounds might serve as interesting candidates for effective antifungal agents.
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KEYWORD
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Chloranthus japonicus Sieb., shizukaol C, shizukaol F, antifungal activity, Phytophthora infestans, Puccinia recondite
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